Rezok-DSR

UNDESIRABLE EFFECTS: Most Common Effect: Headache was the only side effect that occurred in more than 2 percent of people in clinical trials with rabeprazole. Gastrointestinal Side Effects: Several gastrointestinal side effects are rarely associated with rabeprazole. These include constipation or diarrhea, increased or decreased appetite, stomach pain, upset stomach, nausea and vomiting. Other Side Effects: Other unlikely rabeprazole side effects include dizziness, drowsiness, dry mouth, insomnia , nervousness, water retention, and muscle or bone pain. Long-Term Use: A rare side effect with long-term use of over three years is vitamin B-12 deficiency, with symptoms of weakness, sore tongue, and numbness or tingling in the hands or feet.

UNDESIRABLE EFFECTS: Most Common Effect: Headache was the only side effect that occurred in more than 2 percent of people in clinical trials with rabeprazole. Gastrointestinal Side Effects: Several gastrointestinal side effects are rarely associated with rabeprazole. These include constipation or diarrhea, increased or decreased appetite, stomach pain, upset stomach, nausea and vomiting. Other Side Effects: Other unlikely rabeprazole side effects include dizziness, drowsiness, dry mouth, insomnia , nervousness, water retention, and muscle or bone pain. Long-Term Use: A rare side effect with long-term use of over three years is vitamin B-12 deficiency, with symptoms of weakness, sore tongue, and numbness or tingling in the hands or feet.

CONTRAINDICATIONS: Rabeprazole is contraindicated in patients with known hypersensitivity to rabeprazole, substituted benzimidazoles or to any component of the formulation. Clarithromycin is contraindicated in patients with known hypersensitivity to any macrolide antibiotic. Concomitant administration of clarithromycin with pimozide and cisapride is contraindicated. There have been post-marketing reports of drug interactions when clarithromycin and/ or erythromycin are co-administered with pimozide resulting in cardiac arrhythmias (QT prolongation, ventricular tachycardia, ventricular fibrillation, and torsade de pointes) most likely due to inhibition of hepatic metabolism of pimozide by erythromycin and clarithromycin. Amoxicillin is contraindicated in patients with a known hypersensitivity to any penicillin.

DOSAGE AND ADMINISTRATION: One capsule once daily. Special populations: Geriatric: In 20 healthy elderly subjects administered 20 mg rabeprazole once daily for seven days, AUC values approximately doubled and the Cmax increased by 60% compared to values in a parallel younger control group. There was no evidence of drug accumulation after once daily administration. Pediatric: The pharmacokinetics of rabeprazole was studied in 12 adolescent patients with GERD12 to 16 years of age, in a multicenter study. Patients received rabeprazole 20 mg once daily for five or seven days. An approximate 40% increase in exposure was noted following 5 to 7 days of dosing compared with the exposure after 1 day dosing. Pharmacokinetic parameters in adolescent patients with GERD 12 to 16 years of age were within the range observed in healthy adult volunteers. Gender: In analyses adjusted for body mass and height, rabeprazole pharmacokinetics showed no clinically significant differences b...

INDICATIONS: REZOK-DSR is indicated for the relief of symptoms of: Dyspepsia GERD Nausea associated with acid peptic disorders Post-operative nausea and vomiting Chronic gastritis Reflux esophagitis Diabetic gastropathy Non cardiac heart burn Post prandial fullness Stomach and duodenal ulcers Zollinger Ellison Syndrome (ZES)

REZOK-DSR: Highlights Rabeprazole: It blocks the production of acid by the stomach. Greater efficacy than Esomeprazole. Increases intragastric pH for longer duration. More effective in comparison with omeprazole in: o    Daytime symptomic relief in GERD. o    H.pylori eradication                       ·    Rapid and well tolerable therapy in Zollinger-Ellison syndrome than Omeprazole and Lansoprazole. Food has non effect on its absorption.   Minimal propensity for Drug Interaction. Rapid and Complete heartburn relief. 2-10 times greater Anti-secreatory effect than Omeprazole. The acid suppressive effect of Rabeprazole seen at concentration 10mg is minimum which is least as compared to Omeprazole and Lansoprazole. Fastest relief from heart burn, bloating and belching. It prevents acid reflux. Faster gastric emptying. First standard Pro...