Rezok-DSR: Highlights

REZOK-DSR: Highlights

Rabeprazole:

  • It blocks the production of acid by the stomach.
  • Greater efficacy than Esomeprazole. Increases intragastric pH for longer duration.
  • More effective in comparison with omeprazole in:
o   Daytime symptomic relief in GERD.
o   H.pylori eradication                      
  • ·  Rapid and well tolerable therapy in Zollinger-Ellison syndrome than Omeprazole and Lansoprazole.
  • Food has non effect on its absorption.
  •  Minimal propensity for Drug Interaction.
  • Rapid and Complete heartburn relief.
  • 2-10 times greater Anti-secreatory effect than Omeprazole.
  • The acid suppressive effect of Rabeprazole seen at concentration 10mg is minimum which is least as compared to Omeprazole and Lansoprazole.
  • Fastest relief from heart burn, bloating and belching.
  • It prevents acid reflux.
  • Faster gastric emptying.
  • First standard Proton pump Inhibitor
o   100% inhibition of acid secretion
o   In 10 minutes for 24 hour relief
o   No relevant drug interaction
o   Only PPI to give improved GI protection
  • It is best suited for long term management of reflux diseases.
  • Rabeprazole inhibits Helicobacter pylori urease activity by forming disulphide bonds with the active site of the enzyme.
  • Rabeprazole 20 mg once daily has a significantly faster onset of antisecretory activity than omeprazole 20 mg once daily.
Rabeprazole + Domperidone SR (Rationale of Combination)
    • Novel combination of most potent PPI-Rabeprazole and Domperidone, the only prokinetic with anti-emetic action.
    • Sustained Drug Release Technology that offers 24-hrs drug action with minimal side-effects.
    • Once daily dosage compliance.
    • Rabeprazole and domperidone not only provided desired relief of symptoms of GERD but also is very well tolerated. This combination may also improve the quality of life of patients suffering from GERD.
    • Rabeprazole combined with Domperidone could improve symptoms in patients with Functional Dyspepsia.

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